We examined whether activating M-type potassium channels in the left stellate ganglion could help manage heart issues during acute myocardial ischemia (AMI). In our study involving beagles, some received an M-channel activator called retigabine before inducing AMI.
The results were promising—we noticed that retigabine reduced excessive sympathetic activity, leading to fewer arrhythmias. Moreover, it allowed for better heart rhythm stability and increased resistance to ventricular fibrillation compared to those who did not receive treatment. These insights suggest that targeting M-channels could be a valuable approach in reducing heart rhythm disturbances during ischemic events.
Read More
9
ICA-105574 shows promise for LQT2
Molecular insights into the rescue mechanism of an HERG activator against severe LQT2 mutations.
We investigated how ICA-105574, an HERG channel activator, might alleviate severe long QT syndrome type 2 (LQT2) caused by critical genetic mutations. Our study included in vivo experiments with animal models and in vitro tests that showcased ICA-105574's ability to shorten cardiac repolarization intervals.
We found it effectively restored ion currents impacted by harmful mutations. Our findings indicate that ICA-105574 has potential as a therapeutic option and highlight the usefulness of molecular dynamics simulations in drug design for managing HERG-related conditions.
Read More
9
AMPK activation improves endothelial function
AMPK phosphorylation of K2.3 alleviates angiotensin II-induced endothelial dysfunction.
We explored how AMPK, when activated, enhances potassium channels known as K2.3 in endothelial cells, which could improve vascular health. Through various laboratory techniques, we found that AMPK activation increased the phosphorylation of K2.3, leading to better blood flow in mouse models of hypertension. This process seems to reduce early hypertension caused by angiotensin II. Our findings suggest that AMPK could be a valuable target for therapies aimed at treating endothelial dysfunction and hypertension.
Read More
Most Useful Reviews
9
Essential potassium benefits
176 people found this helpful
Potassium is crucial for optimal energy and nerve health, and it significantly helps prevent cardiovascular diseases. I found remarkable results using potassium—it aids in regulating blood pressure and improving oxygen supply to the brain. After using it, I noticed positive changes, particularly for my allergic child. It's a vital mineral, and I recommend it for everyone seeking better health. If my feedback was useful, please click “Yes”.
Read More
9
Alleviates stress impacts
27 people found this helpful
I chose this potassium supplement and experienced positive changes in my health. Sleep has improved, and stress levels have decreased, which is vital for anyone facing cardiovascular issues. The quality is excellent and I recommend maintaining sufficient potassium levels to prevent health problems. Wishing everyone good health!
Read More
9
Enhances energy levels
9 people found this helpful
Potassium is recommended for preventing cardiovascular disease. It helps alleviate night leg cramps and boosts overall energy and nerve health. It regulates water balance in the body and normalises blood pressure, improving oxygen delivery to the brain. I find potassium citrate the best form to stay healthy.
We investigated how ICA-105574, an HERG channel activator, might alleviate severe long QT syndrome type 2 (LQT2) caused by critical genetic mutations. Our study included in vivo experiments with animal models and in vitro tests that showcased ICA-105574's ability to shorten cardiac repolarization intervals.
We found it effectively restored ion currents impacted by harmful mutations. Our findings indicate that ICA-105574 has potential as a therapeutic option and highlight the usefulness of molecular dynamics simulations in drug design for managing HERG-related conditions.
Read More
9
AMPK activation improves endothelial function
AMPK phosphorylation of K2.3 alleviates angiotensin II-induced endothelial dysfunction.
We explored how AMPK, when activated, enhances potassium channels known as K2.3 in endothelial cells, which could improve vascular health. Through various laboratory techniques, we found that AMPK activation increased the phosphorylation of K2.3, leading to better blood flow in mouse models of hypertension. This process seems to reduce early hypertension caused by angiotensin II. Our findings suggest that AMPK could be a valuable target for therapies aimed at treating endothelial dysfunction and hypertension.
Read More
9
M-channel activation mitigates arrhythmias
Targeted M-Channel Activation in the Left Stellate Ganglion Protects Against Ischemia-Induced Ventricular Arrhythmias in Canines.
We examined whether activating M-type potassium channels in the left stellate ganglion could help manage heart issues during acute myocardial ischemia (AMI). In our study involving beagles, some received an M-channel activator called retigabine before inducing AMI.
The results were promising—we noticed that retigabine reduced excessive sympathetic activity, leading to fewer arrhythmias. Moreover, it allowed for better heart rhythm stability and increased resistance to ventricular fibrillation compared to those who did not receive treatment. These insights suggest that targeting M-channels could be a valuable approach in reducing heart rhythm disturbances during ischemic events.
Read More
8
Potassium's role in hypertension treatment
Dyskalemia Prior to and After Initiation of a Fixed Dose Combination of Telmisartan and Amlodipine in Adults with Hypertension in Bangladesh.
We examined the link between potassium levels and the effectiveness of a fixed-dose combination (FDC) of telmisartan and amlodipine in treating hypertension. Our study took place in Dhaka, where we screened individuals for potassium imbalances before and after treatment.
Despite concerns about dyskalemia, we found low rates of both high and low potassium levels among patients. Additionally, the treatment effectively lowered blood pressure, making it a suitable option in settings where lab access is limited.
Overall, this suggests that we can confidently proceed with this treatment regimen.
Read More
8
Salt reduction benefits blood pressure
Effect of Salt Reduction Interventions in Lowering Blood Pressure and Salt Intake in Zhejiang Province, China, 2017-2021: A Randomized Controlled Trial.
We assessed the effectiveness of a salt reduction project in Zhejiang Province, China, focusing on blood pressure and potassium levels. Through thorough surveys and a randomized group approach, we found significant changes post-intervention.
Participants in the intervention areas showed an impressive increase in urinary potassium excretion and a notable decrease in both sodium intake and blood pressure levels. This suggests that a comprehensive, community-focused strategy can effectively tackle high-salt diets and improve cardiovascular health.
Potassium is crucial for optimal energy and nerve health, and it significantly helps prevent cardiovascular diseases. I found remarkable results using potassium—it aids in regulating blood pressure and improving oxygen supply to the brain. After using it, I noticed positive changes, particularly for my allergic child. It's a vital mineral, and I recommend it for everyone seeking better health. If my feedback was useful, please click “Yes”.
Read More
9
Alleviates stress impacts
27 people found this helpful
I chose this potassium supplement and experienced positive changes in my health. Sleep has improved, and stress levels have decreased, which is vital for anyone facing cardiovascular issues. The quality is excellent and I recommend maintaining sufficient potassium levels to prevent health problems. Wishing everyone good health!
Read More
9
Enhances energy levels
9 people found this helpful
Potassium is recommended for preventing cardiovascular disease. It helps alleviate night leg cramps and boosts overall energy and nerve health. It regulates water balance in the body and normalises blood pressure, improving oxygen delivery to the brain. I find potassium citrate the best form to stay healthy.
Read More
9
Regulates heart rate
5 people found this helpful
Potassium strengthens cellular tissues and helps with nerve impulse transmission. It regulates heart rate and maintains energy levels. This mineral is crucial for magnesium accumulation in the body, benefiting both cardiovascular health and brain function.
Read More
9
Reduces sugar cravings
4 people found this helpful
I realised my cravings for sweets stemmed from my body’s inability to transport sugar to necessary organs due to potassium deficiency. After taking potassium, my craving for sweets vanished. However, it’s essential for those with kidney issues to consult a doctor first.
Cardiovascular disease (CVD) is a broad term that encompasses a range of heart and blood vessel disorders. This can include conditions such as coronary artery disease, which leads to heart attacks; cerebrovascular disease that results in strokes; and peripheral artery disease affecting blood flow to the limbs. The key risk factors for CVD often include high blood pressure, high cholesterol, obesity, smoking, a sedentary lifestyle, and diabetes. By identifying and managing these risk factors, individuals can significantly reduce their likelihood of developing cardiovascular problems.
Prevention and treatment strategies often involve lifestyle modifications such as adopting a heart-healthy diet rich in fruits, vegetables, whole grains, and lean proteins, alongside engaging in regular physical activity. In some cases, medications might be necessary to control blood pressure or cholesterol levels. Regular check-ups with a healthcare provider are essential for monitoring heart health, especially for individuals with a family history of CVD. Understanding the signs and symptoms of cardiovascular issues—like chest pain, shortness of breath, or fatigue—can help in seeking timely medical attention, ultimately leading to better outcomes.
Potassium is a vital mineral and electrolyte that plays a crucial role in the body's overall health and function. It's primarily found in fruits, vegetables, legumes, and nuts, making these foods essential for maintaining adequate potassium levels. This mineral is essential for a variety of bodily functions, including regulating fluid balance, nerve signal transmission, and muscle contraction. An adequate intake of potassium can help prevent high blood pressure and reduce the risk of stroke and cardiovascular diseases.
The recommended daily intake of potassium for adults is around 2,500 to 3,000 milligrams, though individual needs may vary based on factors like age, sex, and physical activity levels. Foods that are particularly rich in potassium include bananas, oranges, potatoes, spinach, and avocados. It's essential to consume enough potassium in your diet, as both deficiency and excessive intake can lead to health issues. However, most people can usually meet their potassium needs through a balanced diet. If you're considering potassium supplements, it is advisable to consult with a healthcare professional to avoid potential complications.
Numerous studies suggest that potassium plays a vital role in heart health, particularly in managing cardiovascular disease (CVD). Potassium helps regulate blood pressure by balancing the effects of sodium in the body. High sodium intake is often linked to increased blood pressure— a significant risk factor for cardiovascular disease. By increasing potassium intake through natural food sources like bananas, avocados, spinach, and sweet potatoes, you can potentially reduce blood pressure levels, therefore lowering the risk of heart-related complications.
Moreover, potassium is crucial for maintaining proper heart rhythm and function. Electrolyte imbalances may lead to arrhythmias, which are irregular heartbeats that can increase the risk of stroke and other heart issues. While increasing potassium intake as part of a balanced diet is generally beneficial, it's important to consult with a healthcare provider before making significant changes, especially for individuals with existing kidney conditions, as excessive potassium can lead to further health complications. Overall, integrating potassium-rich foods into your diet can be a sensible approach to enhancing cardiovascular health.
Users report a variety of experiences regarding the timeframe for noticing results when taking potassium supplements for cardiovascular health. Some individuals have observed improvements within a week of starting the supplement; for instance, one user noted that their blood pressure returned to normal just seven days after initiating potassium with magnesium citrate Read Review. Others have mentioned experiencing positive changes within a month or two, highlighting benefits like improved energy levels, reduced muscle cramps, and better sleep quality Read ReviewRead Review.
However, it is important to note that individual responses can vary based on overall health, existing deficiencies, and concurrent supplementation. Users emphasize the importance of consistent use and potentially combining potassium with magnesium and other vitamins for optimal results Read Review. While the timeline for experiencing noticeable benefits can range from days to several weeks, many users agree that potassium plays a crucial role in supporting cardiovascular health and overall well-being.
Based on the available studies, there are a few insights that suggest potential cardiovascular benefits associated with certain supplements, particularly related to potassium and its effects on blood pressure and overall heart health. For instance, research demonstrates a notable relationship between potassium levels and blood pressure treatment, indicating that adequate potassium intake can support effective hypertension management ([2]). Additionally, a comprehensive strategy involving salt reduction not only lowered blood pressure but also improved potassium balance in participants, suggesting that lifestyle modifications can positively impact cardiovascular health ([5]).
Moreover, the activation of potassium channels has been shown to enhance vascular function and potentially treat endothelial dysfunction associated with hypertension ([3]). While these findings indicate that potassium and related pathways play crucial roles in cardiovascular wellbeing, further research may be necessary to establish direct causative effects of specific supplements on heart disease. Overall, while there is substantial evidence supporting the importance of potassium in cardiovascular health, the broader implication of supplements on cardiovascular disease remains an area for ongoing research.
Users have reported significant improvements in various symptoms after incorporating potassium supplements into their routines. Many have noted enhanced cardiovascular health, with comments highlighting reductions in blood pressure and stabilization of heart rhythms. For instance, one user shared that after experiencing arrhythmias post-COVID, their blood pressure normalized within a week of taking potassium with magnesium citrate Read Review, while another remarked on the ease of falling asleep and reduced tension following supplementation Read Review. Additionally, reports of alleviated leg cramps and decreased muscle weakness were common, suggesting potassium's role in supporting muscle function Read Review, Read Review.
Moreover, users have shared experiences of improved energy levels and overall well-being. For example, one user mentioned feeling revitalized and less fatigued, especially during hot weather when sweating can lead to potassium loss Read Review. Others have reported a reduction in cravings for sweets, linking their improvement to past potassium deficiency Read Review. While individual results will vary, the consensus is that potassium supplements can offer notable benefits across various health dimensions, particularly for those seeking to enhance heart health and alleviate muscular issues.
Users report positive outcomes when combining potassium supplements with other nutrients, particularly magnesium. Many individuals note that this combination enhances their overall cardiovascular health and alleviates symptoms. For example, one user highlighted how taking potassium with magnesium helped stabilize their heart rate and normalize blood pressure after experiencing arrhythmias Read Review. Additionally, another user emphasized the importance of balancing potassium with magnesium and vitamin B6 to improve absorption, which further supports cardiovascular and muscle functions Read Review.
Furthermore, users have reported improvements in energy levels and reductions in muscle cramps by incorporating potassium alongside other supplements like omega and vitamin D, which have collectively diminished feelings of fatigue and muscle weakness Read Review. Others found that potassium combined with magnesium taurine provided significant relief from arrhythmias, underscoring the synergistic effects of these supplements for those managing cardiovascular concerns Read Review. Overall, integrating potassium with other supportive nutrients appears to enhance the supplement's effectiveness in promoting heart health and metabolic functions.
Users widely acknowledge the importance of potassium in managing cardiovascular disease, emphasizing its role in regulating blood pressure and improving overall heart health. Many reviews highlight that maintaining adequate potassium levels can prevent issues like muscle weakness, leg cramps, and arrhythmias. For example, one user noted, "I take potassium at night to alleviate heart palpitations..." showcasing its direct impact on cardiovascular symptoms Read Review. Some users recommend specific dosages, such as taking 2-3 capsules daily, suggesting that higher intake can lead to better health outcomes Read Review.
Additionally, users have reported that combining potassium with magnesium enhances its effectiveness. One review pointed out, "Balancing potassium with magnesium... is advisable for better absorption" Read Review. On the other hand, some users expressed caution, particularly for those with kidney problems, recommending consultation with a healthcare provider before starting supplementation Read Review. Overall, it appears that while potassium supplementation is beneficial for cardiovascular health, specific dosing may vary, necessitating a tailored approach depending on individual health needs.
7.5
Normalises blood pressure
4 people found this helpful
After suffering from cardiac arrhythmias post-COVID, I found my potassium levels were very low. Within a week of taking potassium with magnesium citrate, I noticed an improvement, and my blood pressure returned to normal.
9
Improves sleep quality
3 people found this helpful
After taking potassium with magnesium, I've found it easier to fall asleep and feel overall better. It significantly eases tension, especially for those with cardiovascular issues or potassium deficiencies.
9
Eliminates arrhythmia
1 people found this helpful
I have a congenital heart defect and experienced distressing arrhythmias after stress. Taking potassium with magnesium taurine has helped immensely. I’ve taken it for six months and have not had any arrhythmias since. Potassium supports cardiovascular health by normalising water-salt balance, enhancing nerve impulses, and aiding oxygen supply to brain cells.
9
Protects heart health
6 people found this helpful
Potassium is crucial for heart muscle contraction, blood pressure regulation, and fluid balance. It helps protect against cardiovascular diseases such as heart attacks and strokes, while also normalising digestive function. Deficiency can impact the cardiovascular and nervous systems, muscles, kidneys, and liver. It's important to balance potassium with magnesium; they influence each other’s levels. For better absorption, combining potassium with magnesium and vitamin B6 is advisable.
9
Reduces heart risks
1 people found this helpful
Excellent quality potassium citrate from Now Foods. It fills potassium deficiencies and aids in maintaining cellular potassium levels. Potassium is vital for regulating body functions and prevents issues like heart rhythm problems. This supplement has greatly benefited my overall health.
7.5
Eases arrhythmia symptoms
3 people found this helpful
I suffer from vegetative-vascular dystonia and arrhythmia. Potassium citrate significantly helped this year, unlike apple cider vinegar. This potassium form is better absorbed, and within days my heart rate stabilised.
9
Increases endurance
1 people found this helpful
A great supplement for heart health. Potassium deficiency can lead to weakness and fatigue. I feel more energised, especially in the heat when I sweat and lose electrolytes, including potassium. This supplement effectively replenishes my potassium levels.
9
Reduces sugar cravings
4 people found this helpful
I realised my cravings for sweets stemmed from my body’s inability to transport sugar to necessary organs due to potassium deficiency. After taking potassium, my craving for sweets vanished. However, it’s essential for those with kidney issues to consult a doctor first.
9
Supports heart health
1 people found this helpful
I ordered it for my mum - she loves the effect. Adequate potassium intake can significantly reduce cardiovascular disease risk, as well as high blood pressure. Combining it with omega, vitamin D, magnesium, and vitamin C has reduced her fatigue and muscle weakness.
7.5
Supports heart stability
28 people found this helpful
I take potassium at night to alleviate heart palpitations, especially during the premenopausal period. It's also beneficial for my husband, who suffers from leg cramps at night. For those exerting themselves or on diuretics, I highly recommend potassium for cardiovascular support. If you found this helpful, please give a thumbs up.
9
Reduces stroke risk
109 people found this helpful
Potassium is vital for heart support and muscle function. It contributes to maintaining the acid-base balance, which is crucial for health. I take one capsule 2-3 times daily, and I feel great—the risk of cardiovascular disease has significantly decreased. Inadequate potassium can lead to fatigue and muscle weakness, so I recommend this supplement for those concerned about their heart health.
8
Potassium's role in hypertension treatment
Dyskalemia Prior to and After Initiation of a Fixed Dose Combination of Telmisartan and Amlodipine in Adults with Hypertension in Bangladesh.
We examined the link between potassium levels and the effectiveness of a fixed-dose combination (FDC) of telmisartan and amlodipine in treating hypertension. Our study took place in Dhaka, where we screened individuals for potassium imbalances before and after treatment.
Despite concerns about dyskalemia, we found low rates of both high and low potassium levels among patients. Additionally, the treatment effectively lowered blood pressure, making it a suitable option in settings where lab access is limited.
Overall, this suggests that we can confidently proceed with this treatment regimen.
8
Salt reduction benefits blood pressure
Effect of Salt Reduction Interventions in Lowering Blood Pressure and Salt Intake in Zhejiang Province, China, 2017-2021: A Randomized Controlled Trial.
We assessed the effectiveness of a salt reduction project in Zhejiang Province, China, focusing on blood pressure and potassium levels. Through thorough surveys and a randomized group approach, we found significant changes post-intervention.
Participants in the intervention areas showed an impressive increase in urinary potassium excretion and a notable decrease in both sodium intake and blood pressure levels. This suggests that a comprehensive, community-focused strategy can effectively tackle high-salt diets and improve cardiovascular health.
9
AMPK activation improves endothelial function
AMPK phosphorylation of K2.3 alleviates angiotensin II-induced endothelial dysfunction.
We explored how AMPK, when activated, enhances potassium channels known as K2.3 in endothelial cells, which could improve vascular health. Through various laboratory techniques, we found that AMPK activation increased the phosphorylation of K2.3, leading to better blood flow in mouse models of hypertension. This process seems to reduce early hypertension caused by angiotensin II. Our findings suggest that AMPK could be a valuable target for therapies aimed at treating endothelial dysfunction and hypertension.
References
Kumawat A, Tavazzani E, Lentini G, Trancuccio A, Kukavica D, et al. Molecular insights into the rescue mechanism of an HERG activator against severe LQT2 mutations. J Biomed Sci. 2025;32:40. doi:10.1186/s12929-025-01134-w
Ishigami J, Hasan MM, Sarker A, Nahar S, Shuvo SS, et al. Dyskalemia Prior to and After Initiation of a Fixed Dose Combination of Telmisartan and Amlodipine in Adults with Hypertension in Bangladesh. Glob Heart. 2025;20:30. doi:10.5334/gh.1415
Pang ZD, Wang Y, Han MZ, She G, Sun X, et al. AMPK phosphorylation of K2.3 alleviates angiotensin II-induced endothelial dysfunction. Biochem Pharmacol. 2025;236:116880. doi:10.1016/j.bcp.2025.116880
Peng JQ, Zhou MM, Xu L, Wang X, Tang YH, et al. Targeted M-Channel Activation in the Left Stellate Ganglion Protects Against Ischemia-Induced Ventricular Arrhythmias in Canines. J Am Heart Assoc. 2025;14:e039059. doi:10.1161/JAHA.124.039059
Du X, Zhu Y, Guo J, Chen X, Zhang J, et al. Effect of Salt Reduction Interventions in Lowering Blood Pressure and Salt Intake in Zhejiang Province, China, 2017-2021: A Randomized Controlled Trial. Nutrients. 2025;17. doi:10.3390/nu17050893
Liebman SE, Baran A, Barnett TD, Campbell TM, Chen L, et al. The Effects of a Whole-Food Plant-Based Nutrition Education Program on Blood Pressure and Potassium in Chronic Kidney Disease: A Proof-of-Concept Study. Nutrients. 2025;17. doi:10.3390/nu17050779
Zhang X, Yao S, Wang Y, Chu C, Du M, et al. Associations of microRNA Gene Polymorphisms With Salt Sensitivity, Longitudinal Blood Pressure Changes, and Hypertension Incidence in the Chinese Population. J Clin Hypertens (Greenwich). 2025;27:e70019. doi:10.1111/jch.70019